RELEASE AND RHEOLOGICAL CHARACTERISTICS OF CHLORTETRACYCLINE HYDROCHLORIDE OPHTHALMIC OINTMENTS

Manufacturing Differences on Physicochemical and In Vitro Release Characteristics of Semisolid Ophthalmic Ointments

Synthesis of Metformin Hydrochloride nanoliposomes: Evaluation of physicochemical characteristics and release kinetics

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Synthesis of Metformin Hydrochloride nanoliposomes: Evaluation of physicochemical characteristics and release kinetics

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Lycopene/arabinoxylan gels: rheological and controlled release characteristics.

Arabinoxylan gels exhibiting different rheological and lycopene transport properties were obtained by modifying the polysaccharide concentration from 3 to 4% (w/v). The apparent lycopene diffusion coefficient decreased from 2.7 × 10⁻⁷ to 2.4 × 10⁻⁷ cm²/s as the arabinoxylan concentration in the gel changed from 3 to 4% (w/v). A low amount of lycopene is released by diffusion from arabinoxylan g...

Understanding Kinetics of Drug Release from Ointments

X. Xu, M. Al-Ghabeish, Y. S. Krishnaiah, Z. Rahman, M. A. Khan U.S. Food and Drug Administration Purpose From a drug product quality perspective, in vitro release testing (IVRT) serves many different, yet crucial roles throughout the lifecycle of a drug product. Unfortunately, the maturity of IVRT methods for pharmaceutical ointments is considerably lacking and under-utilized as compared to con...